Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease

Alzheimer disease (AD) and chronic traumatic encephalopathy (CTE) involve the abnormal accumulation in the brain of filaments composed of both three-repeat (3R) and four-repeat (4R) (3R/4R) tau isoforms. To probe the molecular basis for AD’s tau filament propagation and to improve detection of tau a...

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Detalles Bibliográficos
Autores principales: Kraus, Allison, Saijo, Eri, Metrick, Michael A., Newell, Kathy, Sigurdson, Christina J., Zanusso, Gianluigi, Ghetti, Bernardino, Caughey, Byron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426988/
https://www.ncbi.nlm.nih.gov/pubmed/30570675
http://dx.doi.org/10.1007/s00401-018-1947-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426988/
https://www.ncbi.nlm.nih.gov/pubmed/30570675
http://dx.doi.org/10.1007/s00401-018-1947-3

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