Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS

Epitope characterization is critical for elucidating the mechanism of action of drug candidates. However, traditional high-resolution epitope mapping techniques are not well suited for screening numerous drug candidates recognizing a similar target. Here, we use Hydrogen-Deuterium Exchange Mass Spec...

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Detalles Bibliográficos
Autores principales: Puchades, Cristina, Kűkrer, Başak, Diefenbach, Otto, Sneekes-Vriese, Eveline, Juraszek, Jarek, Koudstaal, Wouter, Apetri, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427009/
https://www.ncbi.nlm.nih.gov/pubmed/30894620
http://dx.doi.org/10.1038/s41598-019-41179-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427009/
https://www.ncbi.nlm.nih.gov/pubmed/30894620
http://dx.doi.org/10.1038/s41598-019-41179-0

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