Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis

Recently, we reported that tetrandrine, a natural alkaloid, could inhibit the osteoclastogenesis and bone erosion through enhancing the ubiquitination and degradation of spleen tyrosine kinase (Syk). Herein, we addressed whether and how aryl hydrocarbon receptor (AhR) mediate the effect of tetrandri...

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Detalles Bibliográficos
Autores principales: Jia, Yugai, Tao, Yu, Lv, Changjun, Xia, Yufeng, Wei, Zhifeng, Dai, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427010/
https://www.ncbi.nlm.nih.gov/pubmed/30674869
http://dx.doi.org/10.1038/s41419-018-1286-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427010/
https://www.ncbi.nlm.nih.gov/pubmed/30674869
http://dx.doi.org/10.1038/s41419-018-1286-2

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