Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping

The bromodomain and extra-terminal (BET) bromodomains, particularly BRD4, have been identified as promising therapeutic targets in the treatment of many human disorders such as cancer, inflammation, obesity, and cardiovascular disease. Recently, the discovery of novel BRD4 inhibitors has garnered su...

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Detalles Bibliográficos
Autores principales: Zhang, Zhimin, Gu, Lili, Wang, Beibei, Huang, Wenhai, Zhang, Yanmin, Ma, Zhen, Zeng, Shenxin, Shen, Zhengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427567/
https://www.ncbi.nlm.nih.gov/pubmed/30879350
http://dx.doi.org/10.1080/14756366.2019.1587417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427567/
https://www.ncbi.nlm.nih.gov/pubmed/30879350
http://dx.doi.org/10.1080/14756366.2019.1587417

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