Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity

BACKGROUND: Accumulation of protein aggregates are a major hallmark of progressive neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease. Transgenic Caenorhabditis elegans nematodes expressing the human synaptic protein α-synuclein in body wall muscle show inclusions of agg...

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Detalles Bibliográficos
Autores principales: Wang, Yiru A., Snoek, Basten L., Sterken, Mark G., Riksen, Joost A. G., Stastna, Jana J., Kammenga, Jan E., Harvey, Simon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427842/
https://www.ncbi.nlm.nih.gov/pubmed/30894116
http://dx.doi.org/10.1186/s12864-019-5597-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427842/
https://www.ncbi.nlm.nih.gov/pubmed/30894116
http://dx.doi.org/10.1186/s12864-019-5597-1

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