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TAD fusion score: discovery and ranking the contribution of deletions to genome structure
Deletions that fuse two adjacent topologically associating domains (TADs) can cause severe developmental disorders. We provide a formal method to quantify deletions based on their potential disruption of the three-dimensional genome structure, denoted as the TAD fusion score. Furthermore, we show th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427865/ https://www.ncbi.nlm.nih.gov/pubmed/30898144 http://dx.doi.org/10.1186/s13059-019-1666-7 |