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Knock-Down of Specific Thyroid Hormone Receptor Isoforms Impairs Body Plan Development in Zebrafish

The role of thyroid hormones (THs) in development has been extensively studied, however, the specific molecular mechanisms involved are far from being clear. THs act by binding to TH nuclear receptors (TR) that act as ligand-dependent transcription factors to regulate TH-dependent gene expression. L...

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Detalles Bibliográficos
Autores principales: Lazcano, Iván, Rodríguez-Ortiz, Roberto, Villalobos, Patricia, Martínez-Torres, Ataúlfo, Solís-Saínz, Juan Carlos, Orozco, Aurea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427925/
https://www.ncbi.nlm.nih.gov/pubmed/30930855
http://dx.doi.org/10.3389/fendo.2019.00156