Translation and evaluation of a pre-clinical 5-protein response prediction signature in a breast cancer phase Ib clinical trial

Human protein biomarker discovery relies heavily on pre-clinical models, in particular established cell lines and patient-derived xenografts, but confirmation studies in primary tissue are essential to demonstrate clinical relevance. We describe in this study the process that was followed to clinica...

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Detalles Bibliográficos
Autores principales: Ducret, Axel, James, Ian, Wilson, Sabine, Feilke, Martina, Tebbe, Andreas, Dybowski, Nikolaj, Elschenbroich, Sarah, Klammer, Martin, Blackler, Adele, Liao, Wei-Li, Tian, Yuan, Friess, Thomas, Bossenmaier, Birgit, Dietmann, Gabriele, Schaab, Christoph, Hembrough, Todd, Ceppi, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428264/
https://www.ncbi.nlm.nih.gov/pubmed/30897176
http://dx.doi.org/10.1371/journal.pone.0213892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428264/
https://www.ncbi.nlm.nih.gov/pubmed/30897176
http://dx.doi.org/10.1371/journal.pone.0213892

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