A complete statistical model for calibration of RNA-seq counts using external spike-ins and maximum likelihood theory

A fundamental assumption, common to the vast majority of high-throughput transcriptome analyses, is that the expression of most genes is unchanged among samples and that total cellular RNA remains constant. As the number of analyzed experimental systems increases however, different independent studi...

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Detalles Bibliográficos
Autores principales: Athanasiadou, Rodoniki, Neymotin, Benjamin, Brandt, Nathan, Wang, Wei, Christiaen, Lionel, Gresham, David, Tranchina, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428340/
https://www.ncbi.nlm.nih.gov/pubmed/30856174
http://dx.doi.org/10.1371/journal.pcbi.1006794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428340/
https://www.ncbi.nlm.nih.gov/pubmed/30856174
http://dx.doi.org/10.1371/journal.pcbi.1006794

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