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A complete statistical model for calibration of RNA-seq counts using external spike-ins and maximum likelihood theory
A fundamental assumption, common to the vast majority of high-throughput transcriptome analyses, is that the expression of most genes is unchanged among samples and that total cellular RNA remains constant. As the number of analyzed experimental systems increases however, different independent studi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428340/ https://www.ncbi.nlm.nih.gov/pubmed/30856174 http://dx.doi.org/10.1371/journal.pcbi.1006794 |