Cargando…

The number of active metabolic pathways is bounded by the number of cellular constraints at maximal metabolic rates

Growth rate is a near-universal selective pressure across microbial species. High growth rates require hundreds of metabolic enzymes, each with different nonlinear kinetics, to be precisely tuned within the bounds set by physicochemical constraints. Yet, the metabolic behaviour of many species is ch...

Descripción completa

Detalles Bibliográficos
Autores principales: de Groot, Daan H., van Boxtel, Coco, Planqué, Robert, Bruggeman, Frank J., Teusink, Bas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428345/
https://www.ncbi.nlm.nih.gov/pubmed/30856167
http://dx.doi.org/10.1371/journal.pcbi.1006858