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The number of active metabolic pathways is bounded by the number of cellular constraints at maximal metabolic rates
Growth rate is a near-universal selective pressure across microbial species. High growth rates require hundreds of metabolic enzymes, each with different nonlinear kinetics, to be precisely tuned within the bounds set by physicochemical constraints. Yet, the metabolic behaviour of many species is ch...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428345/ https://www.ncbi.nlm.nih.gov/pubmed/30856167 http://dx.doi.org/10.1371/journal.pcbi.1006858 |