A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

Risk for Atrial Fibrillation (AF), the most common human arrhythmia, has a major genetic component. The T-box transcription factor TBX5 influences human AF risk, and adult-specific Tbx5-mutant mice demonstrate spontaneous AF. We report that TBX5 is critical for cellular Ca(2+) homeostasis, providing...

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Detalles Bibliográficos
Autores principales: Dai, Wenli, Laforest, Brigitte, Tyan, Leonid, Shen, Kaitlyn M, Nadadur, Rangarajan D, Alvarado, Francisco J, Mazurek, Stefan R, Lazarevic, Sonja, Gadek, Margaret, Wang, Yitang, Li, Ye, Valdivia, Hector H, Shen, Le, Broman, Michael T, Moskowitz, Ivan P, Weber, Christopher R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428569/
https://www.ncbi.nlm.nih.gov/pubmed/30896405
http://dx.doi.org/10.7554/eLife.41814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428569/
https://www.ncbi.nlm.nih.gov/pubmed/30896405
http://dx.doi.org/10.7554/eLife.41814

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