Simultaneously down-regulation of multiplex branch pathways using CRISPRi and fermentation optimization for enhancing β-amyrin production in Saccharomyces cerevisiae

The production of β-amyrin in Saccharomyces cerevisiae is still low due to the inability of effectively regulating the endogenous metabolic pathway for competitive synthesis of β-amyrin precursors. In this study, we focused on two branches of β-amyrin synthetics pathway that consume β-amyrin precurs...

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Detalles Bibliográficos
Autores principales: Ni, Jiangping, Zhang, Genlin, Qin, Lei, Li, Jun, Li, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428687/
https://www.ncbi.nlm.nih.gov/pubmed/30949594
http://dx.doi.org/10.1016/j.synbio.2019.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428687/
https://www.ncbi.nlm.nih.gov/pubmed/30949594
http://dx.doi.org/10.1016/j.synbio.2019.02.002

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