DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

Inhibitors of poly(ADP-ribose) polymerase (PARP) have demonstrated efficacy in women with BRCA-mutant ovarian cancer. However, only 15%–20% of ovarian cancers harbor BRCA mutations, therefore additional therapies are required. Here, we show that a subset of ovarian cancer cell lines and ex vivo mode...

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Detalles Bibliográficos
Autores principales: Pillay, Nisha, Tighe, Anthony, Nelson, Louisa, Littler, Samantha, Coulson-Gilmer, Camilla, Bah, Nourdine, Golder, Anya, Bakker, Bjorn, Spierings, Diana C.J., James, Dominic I., Smith, Kate M., Jordan, Allan M., Morgan, Robert D., Ogilvie, Donald J., Foijer, Floris, Jackson, Dean A., Taylor, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428690/
https://www.ncbi.nlm.nih.gov/pubmed/30889383
http://dx.doi.org/10.1016/j.ccell.2019.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428690/
https://www.ncbi.nlm.nih.gov/pubmed/30889383
http://dx.doi.org/10.1016/j.ccell.2019.02.004

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