Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation

The Lin28b(+)Let7(−) axis in fetal/neonatal development plays a role in promoting CD5(+) B1a cell generation as a B-1 B cell developmental outcome. Here we identify the Let7 target, Arid3a, as a crucial molecular effector of the B-1 cell developmental program. Arid3a expression is increased at pro-B...

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Detalles Bibliográficos
Autores principales: Hayakawa, Kyoko, Li, Yue-Sheng, Shinton, Susan A., Bandi, Srinivasa R., Formica, Anthony M., Brill-Dashoff, Joni, Hardy, Richard R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428705/
https://www.ncbi.nlm.nih.gov/pubmed/30930899
http://dx.doi.org/10.3389/fimmu.2019.00457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428705/
https://www.ncbi.nlm.nih.gov/pubmed/30930899
http://dx.doi.org/10.3389/fimmu.2019.00457

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