Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types. Polyomavirus and papillomavirus oncoproteins ind...

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Detalles Bibliográficos
Autores principales: Starrett, Gabriel J., Serebrenik, Artur A., Roelofs, Pieter A., McCann, Jennifer L., Verhalen, Brandy, Jarvis, Matthew C., Stewart, Teneale A., Law, Emily K., Krupp, Annabel, Jiang, Mengxi, Martens, John W. M., Cahir-McFarland, Ellen, Span, Paul N., Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428753/
https://www.ncbi.nlm.nih.gov/pubmed/30723127
http://dx.doi.org/10.1128/mBio.02690-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428753/
https://www.ncbi.nlm.nih.gov/pubmed/30723127
http://dx.doi.org/10.1128/mBio.02690-18

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