A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection

Encephalomyocarditis virus (EMCV) is a picornavirus that produces lytic infections in murine and human cells. Employing a genome-wide CRISPR-Cas9 knockout screen to find host factors required for EMCV infection, we identified a role for ADAM9 in EMCV infection. CRISPR-mediated deletion of ADAM9 in m...

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Detalles Bibliográficos
Autores principales: Bazzone, Lindsey E., King, Michael, MacKay, Christopher R., Kyawe, Pyae P., Meraner, Paul, Lindstrom, Daniel, Rojas-Quintero, Joselyn, Owen, Caroline A., Wang, Jennifer P., Brass, Abraham L., Kurt-Jones, Evelyn A., Finberg, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428755/
https://www.ncbi.nlm.nih.gov/pubmed/30723129
http://dx.doi.org/10.1128/mBio.02734-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428755/
https://www.ncbi.nlm.nih.gov/pubmed/30723129
http://dx.doi.org/10.1128/mBio.02734-18

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