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A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection
Encephalomyocarditis virus (EMCV) is a picornavirus that produces lytic infections in murine and human cells. Employing a genome-wide CRISPR-Cas9 knockout screen to find host factors required for EMCV infection, we identified a role for ADAM9 in EMCV infection. CRISPR-mediated deletion of ADAM9 in m...
Autores principales: | Bazzone, Lindsey E., King, Michael, MacKay, Christopher R., Kyawe, Pyae P., Meraner, Paul, Lindstrom, Daniel, Rojas-Quintero, Joselyn, Owen, Caroline A., Wang, Jennifer P., Brass, Abraham L., Kurt-Jones, Evelyn A., Finberg, Robert W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428755/ https://www.ncbi.nlm.nih.gov/pubmed/30723129 http://dx.doi.org/10.1128/mBio.02734-18 |
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