Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole

The Q fever agent Coxiella burnetii is a Gram-negative bacterium that invades macrophages and replicates inside a specialized lysosomal vacuole. The pathogen employs a type 4B secretion system (T4BSS) to deliver effector proteins into the host cell that modify the Coxiella-containing vacuole (CCV) i...

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Detalles Bibliográficos
Autores principales: Larson, Charles L., Sandoz, Kelsi M., Cockrell, Diane C., Heinzen, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428759/
https://www.ncbi.nlm.nih.gov/pubmed/30723133
http://dx.doi.org/10.1128/mBio.02816-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428759/
https://www.ncbi.nlm.nih.gov/pubmed/30723133
http://dx.doi.org/10.1128/mBio.02816-18

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