Machine learning-powered antibiotics phenotypic drug discovery

Identification of novel antibiotics remains a major challenge for drug discovery. The present study explores use of phenotypic readouts beyond classical antibacterial growth inhibition adopting a combined multiparametric high content screening and genomic approach. Deployment of the semi-automated b...

Descripción completa

Detalles Bibliográficos
Autores principales: Zoffmann, Sannah, Vercruysse, Maarten, Benmansour, Fethallah, Maunz, Andreas, Wolf, Luise, Blum Marti, Rita, Heckel, Tobias, Ding, Haiyuan, Truong, Hoa Hue, Prummer, Michael, Schmucki, Roland, Mason, Clive S., Bradley, Kenneth, Jacob, Asha Ivy, Lerner, Christian, Araujo del Rosario, Andrea, Burcin, Mark, Amrein, Kurt E., Prunotto, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428806/
https://www.ncbi.nlm.nih.gov/pubmed/30899034
http://dx.doi.org/10.1038/s41598-019-39387-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428806/
https://www.ncbi.nlm.nih.gov/pubmed/30899034
http://dx.doi.org/10.1038/s41598-019-39387-9

Ejemplares similares