Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis

Gliomas are incurable solid tumors with extremely high relapse rate and definite mortality. As gliomas readily acquire resistance to only approved drug, temozolomide (TMZ), there is increasing need to overcome drug resistance by novel therapeutics or by repurposing the existing therapy. In the curre...

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Detalles Bibliográficos
Autores principales: Pandey, Vimal, Ranjan, Nikhil, Narne, Parimala, Babu, Phanithi Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428853/
https://www.ncbi.nlm.nih.gov/pubmed/30899038
http://dx.doi.org/10.1038/s41598-019-41380-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428853/
https://www.ncbi.nlm.nih.gov/pubmed/30899038
http://dx.doi.org/10.1038/s41598-019-41380-1

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