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Targeting hormone refractory prostate cancer by in vivo selected DNA libraries in an orthotopic xenograft mouse model
The targeting of specific tissue is a major challenge for the effective use of therapeutics and agents mediating this targeting are strongly demanded. We report here on an in vivo selection technology that enables the de novo identification of pegylated DNA aptamers pursuing tissue sites harbouring...
Autores principales: | Civit, Laia, Theodorou, Ioanna, Frey, Franziska, Weber, Holger, Lingnau, Andreas, Gröber, Carsten, Blank, Michael, Dambrune, Chloé, Stunden, James, Beyer, Marc, Schultze, Joachim, Latz, Eicke, Ducongé, Frédéric, Kubbutat, Michael H. G., Mayer, Günter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428855/ https://www.ncbi.nlm.nih.gov/pubmed/30899039 http://dx.doi.org/10.1038/s41598-019-41460-2 |
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