The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins

The highly conserved 5’–3’ exonuclease Xrn1 regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating transcriptome-wide analyses of translation with biochemical and functional studies, we demonstrate an unanticipated regulatory role of Xrn...

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Detalles Bibliográficos
Autores principales: Blasco-Moreno, Bernat, de Campos-Mata, Leire, Böttcher, René, García-Martínez, José, Jungfleisch, Jennifer, Nedialkova, Danny D., Chattopadhyay, Shiladitya, Gas, María-Eugenia, Oliva, Baldomero, Pérez-Ortín, José E., Leidel, Sebastian A., Choder, Mordechai, Díez, Juana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428865/
https://www.ncbi.nlm.nih.gov/pubmed/30899024
http://dx.doi.org/10.1038/s41467-019-09199-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428865/
https://www.ncbi.nlm.nih.gov/pubmed/30899024
http://dx.doi.org/10.1038/s41467-019-09199-6

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