Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR

NvTRPM2 (Nematostella vectensis Transient Receptor Potential Melastatin 2), the species variant of the human apoptosis-related cation channel hTRPM2, is gated by ADP-ribose (ADPR) independently of the C-terminal NUDT9H domain that mediates ADPR-directed gating in hTRPM2. The decisive binding site in...

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Detalles Bibliográficos
Autores principales: Kühn, Frank J. P., Watt, Joanna M., Potter, Barry V. L., Lückhoff, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428886/
https://www.ncbi.nlm.nih.gov/pubmed/30899048
http://dx.doi.org/10.1038/s41598-019-41531-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428886/
https://www.ncbi.nlm.nih.gov/pubmed/30899048
http://dx.doi.org/10.1038/s41598-019-41531-4

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