DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD(+) depletion in experimental atrial fibrillation

Atrial fibrillation (AF) is the most common clinical tachyarrhythmia with a strong tendency to progress in time. AF progression is driven by derailment of protein homeostasis, which ultimately causes contractile dysfunction of the atria. Here we report that tachypacing-induced functional loss of atr...

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Detalles Bibliográficos
Autores principales: Zhang, Deli, Hu, Xu, Li, Jin, Liu, Jia, Baks-te Bulte, Luciënne, Wiersma, Marit, Malik, Noor-ul-Ann, van Marion, Denise M. S., Tolouee, Marziyeh, Hoogstra-Berends, Femke, Lanters, Eva A. H., van Roon, Arie M., de Vries, Antoine A. F., Pijnappels, Daniël A., de Groot, Natasja M. S., Henning, Robert H., Brundel, Bianca J. J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428932/
https://www.ncbi.nlm.nih.gov/pubmed/30898999
http://dx.doi.org/10.1038/s41467-019-09014-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428932/
https://www.ncbi.nlm.nih.gov/pubmed/30898999
http://dx.doi.org/10.1038/s41467-019-09014-2

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