In Silico Molecular Docking and In Vivo Validation with Caenorhabditis elegans to Discover Molecular Initiating Events in Adverse Outcome Pathway Framework: Case Study on Endocrine-Disrupting Chemicals with Estrogen and Androgen Receptors

Molecular docking is used to analyze structural complexes of a target with its ligand for understanding the chemical and structural basis of target specificity. This method has the potential to be applied for discovering molecular initiating events (MIEs) in the Adverse Outcome Pathway framework. In...

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Detalles Bibliográficos
Autores principales: Jeong, Jaeseong, Kim, Hunbeen, Choi, Jinhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429066/
https://www.ncbi.nlm.nih.gov/pubmed/30857347
http://dx.doi.org/10.3390/ijms20051209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429066/
https://www.ncbi.nlm.nih.gov/pubmed/30857347
http://dx.doi.org/10.3390/ijms20051209

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