Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H(2)S/K(ATP) Pathways and Blockade of α(1)-Adrenoceptors and Calcium Channels

Recently, our research group demonstrated that uvaol and ursolic acid increase NO and H(2)S production in aortic tissue. Molecular docking studies showed that both compounds bind with high affinity to endothelial NO synthase (eNOS) and cystathionine gamma-lyase (CSE). The aim of this study was to id...

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Detalles Bibliográficos
Autores principales: Medina-Ruiz, Daniella, Erreguin-Luna, Berenice, Luna-Vázquez, Francisco J., Romo-Mancillas, Antonio, Rojas-Molina, Alejandra, Ibarra-Alvarado, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429095/
https://www.ncbi.nlm.nih.gov/pubmed/30862086
http://dx.doi.org/10.3390/molecules24050987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429095/
https://www.ncbi.nlm.nih.gov/pubmed/30862086
http://dx.doi.org/10.3390/molecules24050987

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