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Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H(2)S/K(ATP) Pathways and Blockade of α(1)-Adrenoceptors and Calcium Channels
Recently, our research group demonstrated that uvaol and ursolic acid increase NO and H(2)S production in aortic tissue. Molecular docking studies showed that both compounds bind with high affinity to endothelial NO synthase (eNOS) and cystathionine gamma-lyase (CSE). The aim of this study was to id...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429095/ https://www.ncbi.nlm.nih.gov/pubmed/30862086 http://dx.doi.org/10.3390/molecules24050987 |