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A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context

We review the preparation of new compounds with good solution and cell uptake properties that can selectively recognize mixed A·T and G·C bp sequences of DNA. Our underlying aim is to show that these new compounds provide important new biotechnology reagents as well as a new class of therapeutic can...

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Detalles Bibliográficos
Autores principales: Paul, Ananya, Guo, Pu, Boykin, David W., Wilson, W. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429135/
https://www.ncbi.nlm.nih.gov/pubmed/30866557
http://dx.doi.org/10.3390/molecules24050946