Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of (68)Ga-Labeled Tracers

Affibody-based imaging of HER3 is a promising approach for patient stratification. We investigated the influence of a hydrophilic HEHEHE-tag ((HE)(3)-tag) and two different gallium-68/chelator-complexes on the biodistribution of Z(08698) with the aim to improve the tracer for PET imaging. Affibody m...

Descripción completa

Detalles Bibliográficos
Autores principales: Dahlsson Leitao, Charles, Rinne, Sara S., Mitran, Bogdan, Vorobyeva, Anzhelika, Andersson, Ken G., Tolmachev, Vladimir, Ståhl, Stefan, Löfblom, John, Orlova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429182/
https://www.ncbi.nlm.nih.gov/pubmed/30832342
http://dx.doi.org/10.3390/ijms20051080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429182/
https://www.ncbi.nlm.nih.gov/pubmed/30832342
http://dx.doi.org/10.3390/ijms20051080

Ejemplares similares