Synthesis and Broad Antiviral Activity of Novel 2-aryl-isoindolin-1-ones towards Diverse Enterovirus A71 Clinical Isolates

Enterovirus 71 (EV-A71) is the main causative pathogen of childhood hand, foot and mouth disease. Effective medicine is currently unavailable for the treatment of this viral disease. Using the fragment-hopping strategy, a series of 2-aryl-isoindolin-1-one compounds were designed, synthesized and inv...

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Detalles Bibliográficos
Autores principales: Wang, Yixuan, Wang, Huiqiang, Jiang, Xinbei, Jiang, Zhi, Guo, Tingting, Ji, Xingyue, Li, Yanping, Li, Yuhuan, Li, Zhuorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429200/
https://www.ncbi.nlm.nih.gov/pubmed/30862068
http://dx.doi.org/10.3390/molecules24050985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429200/
https://www.ncbi.nlm.nih.gov/pubmed/30862068
http://dx.doi.org/10.3390/molecules24050985

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