One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water

A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide th...

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Detalles Bibliográficos
Autores principales: Chen, Liang, Zhu, Huajian, Wang, Jiang, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429224/
https://www.ncbi.nlm.nih.gov/pubmed/30836604
http://dx.doi.org/10.3390/molecules24050893
Descripción
Sumario:A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.

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