Cargando…
One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water
A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide th...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429224/ https://www.ncbi.nlm.nih.gov/pubmed/30836604 http://dx.doi.org/10.3390/molecules24050893 |
_version_ | 1783405548332384256 |
---|---|
author | Chen, Liang Zhu, Huajian Wang, Jiang Liu, Hong |
author_facet | Chen, Liang Zhu, Huajian Wang, Jiang Liu, Hong |
author_sort | Chen, Liang |
collection | PubMed |
description | A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions. |
format | Online Article Text |
id | pubmed-6429224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64292242019-04-15 One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water Chen, Liang Zhu, Huajian Wang, Jiang Liu, Hong Molecules Article A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions. MDPI 2019-03-04 /pmc/articles/PMC6429224/ /pubmed/30836604 http://dx.doi.org/10.3390/molecules24050893 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Liang Zhu, Huajian Wang, Jiang Liu, Hong One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water |
title | One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water |
title_full | One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water |
title_fullStr | One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water |
title_full_unstemmed | One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water |
title_short | One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water |
title_sort | one-pot nbs-promoted synthesis of imidazoles and thiazoles from ethylarenes in water |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429224/ https://www.ncbi.nlm.nih.gov/pubmed/30836604 http://dx.doi.org/10.3390/molecules24050893 |
work_keys_str_mv | AT chenliang onepotnbspromotedsynthesisofimidazolesandthiazolesfromethylarenesinwater AT zhuhuajian onepotnbspromotedsynthesisofimidazolesandthiazolesfromethylarenesinwater AT wangjiang onepotnbspromotedsynthesisofimidazolesandthiazolesfromethylarenesinwater AT liuhong onepotnbspromotedsynthesisofimidazolesandthiazolesfromethylarenesinwater |