One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water

A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide th...

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Detalles Bibliográficos
Autores principales: Chen, Liang, Zhu, Huajian, Wang, Jiang, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429224/
https://www.ncbi.nlm.nih.gov/pubmed/30836604
http://dx.doi.org/10.3390/molecules24050893
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author Chen, Liang
Zhu, Huajian
Wang, Jiang
Liu, Hong
author_facet Chen, Liang
Zhu, Huajian
Wang, Jiang
Liu, Hong
author_sort Chen, Liang
collection PubMed
description A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.
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spelling pubmed-64292242019-04-15 One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water Chen, Liang Zhu, Huajian Wang, Jiang Liu, Hong Molecules Article A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions. MDPI 2019-03-04 /pmc/articles/PMC6429224/ /pubmed/30836604 http://dx.doi.org/10.3390/molecules24050893 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Liang
Zhu, Huajian
Wang, Jiang
Liu, Hong
One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water
title One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water
title_full One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water
title_fullStr One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water
title_full_unstemmed One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water
title_short One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water
title_sort one-pot nbs-promoted synthesis of imidazoles and thiazoles from ethylarenes in water
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429224/
https://www.ncbi.nlm.nih.gov/pubmed/30836604
http://dx.doi.org/10.3390/molecules24050893
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AT wangjiang onepotnbspromotedsynthesisofimidazolesandthiazolesfromethylarenesinwater
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