Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII

A novel series of 8-substituted coumarin-based compounds, characterized by the presence of alkylpiperazine and arylpiperazine chains, were synthesized and tested for their inhibitory activity against four human carbonic anhydrase (hCA) isoforms. All compounds displayed nanomolar potency against the...

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Detalles Bibliográficos
Autores principales: Buran, Kerem, Bua, Silvia, Poli, Giulio, Önen Bayram, F. Esra, Tuccinardi, Tiziano, T. Supuran, Claudiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429297/
https://www.ncbi.nlm.nih.gov/pubmed/30857344
http://dx.doi.org/10.3390/ijms20051208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429297/
https://www.ncbi.nlm.nih.gov/pubmed/30857344
http://dx.doi.org/10.3390/ijms20051208

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