Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins

Isocitrate dehydrogenases (IDH) 1 and 2 are key metabolic enzymes that generate reduced nicotinamide adenine dinucleotide phosphate (NADPH) to maintain a pool of reduced glutathione and peroxiredoxin, and produce α-ketoglutarate, a co-factor of numerous enzymes. IDH1/2 is mutated in ~70–80% of lower...

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Detalles Bibliográficos
Autores principales: Kaminska, Bozena, Czapski, Bartosz, Guzik, Rafal, Król, Sylwia Katarzyna, Gielniewski, Bartlomiej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429355/
https://www.ncbi.nlm.nih.gov/pubmed/30857299
http://dx.doi.org/10.3390/molecules24050968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429355/
https://www.ncbi.nlm.nih.gov/pubmed/30857299
http://dx.doi.org/10.3390/molecules24050968

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