Exploration of Catalytic Selectivity for Aminotransferase (BtrR) Based on Multiple Molecular Dynamics Simulations

The aminotransferase from Bacillus circulans (BtrR), which is involved in the biosynthesis of butirosin, catalyzes the pyridoxal phosphate (PLP)-dependent transamination reaction to convert valienone to β-valienamine (a new β-glycosidase inhibitor for the treatment of lysosomal storage diseases) wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ye, Wan, Youzhong, Zhu, Jingxuan, Li, Muxin, Yu, Zhengfei, Han, Jiarui, Zhang, Zuoming, Han, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429434/
https://www.ncbi.nlm.nih.gov/pubmed/30857183
http://dx.doi.org/10.3390/ijms20051188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429434/
https://www.ncbi.nlm.nih.gov/pubmed/30857183
http://dx.doi.org/10.3390/ijms20051188

Ejemplares similares