Histone Deacetylase Inhibitor, Trichostatin A, Synergistically Enhances Paclitaxel-Induced Cytotoxicity in Urothelial Carcinoma Cells by Suppressing the ERK Pathway

Trichostatin A (TSA), an antifungal antibiotic derived from Streptomyces, inhibits mammalian histone deacetylases, and especially, selectively inhibits class I and II histone deacetylase (HDAC) families of enzymes. TSA reportedly elicits an antiproliferative response in multifarious tumors. This stu...

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Detalles Bibliográficos
Autores principales: Hsu, Fu-Shun, Wu, June-Tai, Lin, Jing-Yi, Yang, Shao-Ping, Kuo, Kuan-Lin, Lin, Wei-Chou, Shi, Chung-Sheng, Chow, Po-Ming, Liao, Shih-Ming, Pan, Chun-I, Hong, Jo-Yu, Chang, Hong-Chiang, Huang, Kuo-How
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429437/
https://www.ncbi.nlm.nih.gov/pubmed/30866433
http://dx.doi.org/10.3390/ijms20051162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429437/
https://www.ncbi.nlm.nih.gov/pubmed/30866433
http://dx.doi.org/10.3390/ijms20051162

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