Design, Synthesis, and Biological Evaluation of Novel Nitrogen Heterocycle-Containing Ursolic Acid Analogs as Antitumor Agents

Nineteen ursolic acid analogues were designed, synthesized, and evaluated for their antiproliferative activity against the Hela and MKN45 cell lines. Some compounds containing a piperazine moiety displayed moderate to high levels of antitumor activities against the tested cancer cell lines. The most...

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Detalles Bibliográficos
Autores principales: Wang, Wenzhi, Lei, Lei, Liu, Zhi, Wang, Hongbo, Meng, Qingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429512/
https://www.ncbi.nlm.nih.gov/pubmed/30832266
http://dx.doi.org/10.3390/molecules24050877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429512/
https://www.ncbi.nlm.nih.gov/pubmed/30832266
http://dx.doi.org/10.3390/molecules24050877

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