Cargando…

Design, Synthesis, and Biological Evaluation of Novel Nitrogen Heterocycle-Containing Ursolic Acid Analogs as Antitumor Agents

Nineteen ursolic acid analogues were designed, synthesized, and evaluated for their antiproliferative activity against the Hela and MKN45 cell lines. Some compounds containing a piperazine moiety displayed moderate to high levels of antitumor activities against the tested cancer cell lines. The most...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Wenzhi, Lei, Lei, Liu, Zhi, Wang, Hongbo, Meng, Qingguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429512/ https://www.ncbi.nlm.nih.gov/pubmed/30832266 http://dx.doi.org/10.3390/molecules24050877

Ejemplares similares

Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents
por: Tran, Tuyen N., et al.
Publicado: (2022)

Betulinic Acid-Nitrogen Heterocyclic Derivatives: Design, Synthesis, and Antitumor Evaluation in Vitro
por: Yang, Yuqin, et al.
Publicado: (2020)

Synthesis and Discovery of Ligustrazine–Heterocycle Derivatives as Antitumor Agents
por: Ma, Shitang, et al.
Publicado: (2022)

Synthesis and anticancer activity of podophyllotoxin derivatives with nitrogen-containing heterocycles
por: Yin, Meng, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Novel 1-Alkyl-tryptophan Analogs as Potential Antitumor Agents
por: Sun, Ting, et al.
Publicado: (2009)

Nitrogen-Containing Apigenin Analogs: Preparation and Biological Activity
por: Liu, Rui, et al.
Publicado: (2012)

Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups
por: Wang, Qi, et al.
Publicado: (2022)

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective
por: Kumar, Adarsh, et al.
Publicado: (2023)

Synthesis and Antitumor Activity of Triazole-Containing Sorafenib Analogs
por: Ye, Wenjing, et al.
Publicado: (2017)

N-tert-Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles
por: Mendes, Joseane A, et al.
Publicado: (2021)

The Application of Microwaves, Ultrasounds, and Their Combination in the Synthesis of Nitrogen-Containing Bicyclic Heterocycles
por: Frecentese, Francesco, et al.
Publicado: (2023)

Advances in the synthesis of nitrogen-containing heterocyclic compounds by in situ benzyne cycloaddition
por: Yu, Hui, et al.
Publicado: (2023)

An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds
por: Ebenezer, Oluwakemi, et al.
Publicado: (2022)

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications
por: Ullah, Faiz, et al.
Publicado: (2022)

Ursolic Acid Analogs as Potential Therapeutics for Cancer
por: Panda, Siva S., et al.
Publicado: (2022)

Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
por: Hemmerling, Franziska, et al.
Publicado: (2016)

Prescribed drugs containing nitrogen heterocycles: an overview
por: Heravi, Majid M., et al.
Publicado: (2020)

Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry
por: Henary, Maged, et al.
Publicado: (2020)

Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls
por: Arcadi, Antonio, et al.
Publicado: (2023)

Theoretical Study on the Complexes of Benzene with Isoelectronic Nitrogen-Containing Heterocycles
por: Wang, Weizhou, et al.
Publicado: (2008)

Synthesis of Novel Nitrogen-Containing Heterocycle Bromophenols and Their Interaction with Keap1 Protein by Molecular Docking
por: Feng, Xiu E., et al.
Publicado: (2017)

Green Synthesis of Aromatic Nitrogen-Containing Heterocycles by Catalytic and Non-Traditional Activation Methods
por: Vlocskó, R. Bernadett, et al.
Publicado: (2023)

Heterocyclic Analogs of Thioflavones: Synthesis and NMR Spectroscopic Investigations (†)
por: Fuchs, Ferdinand C., et al.
Publicado: (2009)

Recent advances in synthesizing and utilizing nitrogen-containing heterocycles
por: Ha, Hyun-Joon
Publicado: (2023)

Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
por: Malek, Fouad, et al.
Publicado: (2022)

A novel and robust heterogeneous Cu catalyst using modified lignosulfonate as support for the synthesis of nitrogen-containing heterocycles
por: Lai, Bingbing, et al.
Publicado: (2020)

Recent developments on microwave-assisted organic synthesis of nitrogen- and oxygen-containing preferred heterocyclic scaffolds
por: Tiwari, Ghanshyam, et al.
Publicado: (2023)

Synthesis of heterocyclic analogs of isoflavone and homoisoflavone based on 3-formylchromone
por: Shatokhin, S. S., et al.
Publicado: (2021)

Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review
por: Siddiqui, Nadeem, et al.
Publicado: (2011)

The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles
por: Masdeu, Carme, et al.
Publicado: (2023)

Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents
por: Kakkar, Saloni, et al.
Publicado: (2018)

Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents
por: Tahlan, Sumit, et al.
Publicado: (2019)

Synthesis and biological evaluation of ursolic acid derivatives bearing triazole moieties as potential anti-Toxoplasma gondii agents
por: Luan, Tian, et al.
Publicado: (2019)

Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents
por: Michalak, Olga, et al.
Publicado: (2023)

Alcohols as Alkylating Agents in the Cation‐Induced Formation of Nitrogen Heterocycles
por: Cox, Lydia, et al.
Publicado: (2022)

Ultrasonic-Assisted Synthesis of Heterocyclic Curcumin Analogs as Antidiabetic, Antibacterial, and Antioxidant Agents Combined with in vitro and in silico Studies
por: Zelelew, Demis, et al.
Publicado: (2023)

Synthesis of Nitrogen Heterocycles Using Samarium(II) Iodide
por: Shi, Shicheng, et al.
Publicado: (2017)

Microwave assisted synthesis of five membered nitrogen heterocycles
por: Meera, Gopinadh, et al.
Publicado: (2020)

Synthesis and Antibacterial and Antifungal Studies of Novel Nitrogen Containing Heterocycles from 5-Ethylpyridin-2-ethanol
por: Patel, N. B., et al.
Publicado: (2010)

The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells
por: Gao, Yuan, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_om9rg0eo8ctbe7c2au1faqt55u