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Design, Synthesis, and Biological Evaluation of Novel Nitrogen Heterocycle-Containing Ursolic Acid Analogs as Antitumor Agents
Nineteen ursolic acid analogues were designed, synthesized, and evaluated for their antiproliferative activity against the Hela and MKN45 cell lines. Some compounds containing a piperazine moiety displayed moderate to high levels of antitumor activities against the tested cancer cell lines. The most...
Autores principales: | Wang, Wenzhi, Lei, Lei, Liu, Zhi, Wang, Hongbo, Meng, Qingguo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429512/ https://www.ncbi.nlm.nih.gov/pubmed/30832266 http://dx.doi.org/10.3390/molecules24050877 |
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