Fast Methods for Prediction of Aldehyde Oxidase-Mediated Site-of-Metabolism

Aldehyde Oxidase (AO) is an enzyme involved in the metabolism of aldehydes and N-containing heterocyclic compounds. Many drug compounds contain heterocyclic moieties, and AO metabolism has lead to failure of several late-stage drug candidates. Therefore, it is important to take AO-mediated metabolis...

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Detalles Bibliográficos
Autores principales: Montefiori, Marco, Lyngholm-Kjærby, Casper, Long, Anthony, Olsen, Lars, Jørgensen, Flemming Steen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429535/
https://www.ncbi.nlm.nih.gov/pubmed/30949305
http://dx.doi.org/10.1016/j.csbj.2019.03.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429535/
https://www.ncbi.nlm.nih.gov/pubmed/30949305
http://dx.doi.org/10.1016/j.csbj.2019.03.003

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