Aggrecan Hypomorphism Compromises Articular Cartilage Biomechanical Properties and Is Associated with Increased Incidence of Spontaneous Osteoarthritis

The gene encoding the proteoglycan aggrecan (Agc1) is abundantly expressed in cartilage during development and adulthood, and the loss or diminished deposition of the protein results in a wide range of skeletal malformations. Furthermore, aggrecan degradation is a hallmark of cartilage degeneration...

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Detalles Bibliográficos
Autores principales: Alberton, Paolo, Dugonitsch, Hans Christian, Hartmann, Bastian, Li, Ping, Farkas, Zsuzsanna, Saller, Maximilian Michael, Clausen-Schaumann, Hauke, Aszodi, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429589/
https://www.ncbi.nlm.nih.gov/pubmed/30813547
http://dx.doi.org/10.3390/ijms20051008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429589/
https://www.ncbi.nlm.nih.gov/pubmed/30813547
http://dx.doi.org/10.3390/ijms20051008

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