Cooperativity basis for small-molecule stabilization of protein–protein interactions

A cooperativity framework to describe and interpret small-molecule stabilization of protein–protein interactions (PPI) is presented. The stabilization of PPIs is a versatile and emerging therapeutic strategy to target specific combinations of protein partners within the protein interactome. Currentl...

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Detalles Bibliográficos
Autores principales: de Vink, Pim J., Andrei, Sebastian A., Higuchi, Yusuke, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429609/
https://www.ncbi.nlm.nih.gov/pubmed/30996864
http://dx.doi.org/10.1039/c8sc05242e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429609/
https://www.ncbi.nlm.nih.gov/pubmed/30996864
http://dx.doi.org/10.1039/c8sc05242e

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