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Cooperativity basis for small-molecule stabilization of protein–protein interactions

A cooperativity framework to describe and interpret small-molecule stabilization of protein–protein interactions (PPI) is presented. The stabilization of PPIs is a versatile and emerging therapeutic strategy to target specific combinations of protein partners within the protein interactome. Currentl...

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Detalles Bibliográficos
Autores principales:	de Vink, Pim J., Andrei, Sebastian A., Higuchi, Yusuke, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429609/ https://www.ncbi.nlm.nih.gov/pubmed/30996864 http://dx.doi.org/10.1039/c8sc05242e

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