KRAS and NRAS pyrosequencing screening in Tunisian colorectal cancer patients in 2015

BACKGROUND: Mutations in KRAS and NRAS often result in constitutive activation of RAS in the epidermal growth factor receptor (EGFR) signaling pathway. Mutations in KRAS exon 2 (codon 12–13) predict resistance to anti-EGFR targeted therapy in patients with metastatic colorectal carcinoma (mCRC). How...

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Detalles Bibliográficos
Autores principales: Jouini, Raja, Ferchichi, Marwa, BenBrahim, Ehsen, Ayari, Imen, Khanchel, Fatma, Koubaa, Wafa, Saidi, Olfa, Allani, Riadh, Chadli-Debbiche, Aschraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430077/
https://www.ncbi.nlm.nih.gov/pubmed/30949599
http://dx.doi.org/10.1016/j.heliyon.2019.e01330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430077/
https://www.ncbi.nlm.nih.gov/pubmed/30949599
http://dx.doi.org/10.1016/j.heliyon.2019.e01330

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