Assessing CYP2C19 Ontogeny in Neonates and Infants Using Physiologically Based Pharmacokinetic Models: Impact of Enzyme Maturation Versus Inhibition

The objective of this study was to develop pediatric physiologically based pharmacokinetic (PBPK) models for pantoprazole and esomeprazole. Pediatric PBPK models were developed by Simcyp version 15 by incorporating cytochrome P450 (CYP)2C19 maturation and auto‐inhibition. The predicted‐to‐observed p...

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Detalles Bibliográficos
Autores principales: Duan, Peng, Wu, Fang, Moore, Jason N., Fisher, Jeffrey, Crentsil, Victor, Gonzalez, Daniel, Zhang, Lei, Burckart, Gilbert J., Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430158/
https://www.ncbi.nlm.nih.gov/pubmed/30520273
http://dx.doi.org/10.1002/psp4.12350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430158/
https://www.ncbi.nlm.nih.gov/pubmed/30520273
http://dx.doi.org/10.1002/psp4.12350

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