Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation

Parkinson’s Disease (PD) is a neurodegenerative disease for which there currently is no cure. Aggregation of the pre-synaptic protein α-synuclein (aSN) into oligomers (αSOs) is believed to play a key role in PD pathology, but little is known about αSO formation in vivo and how they induce neurodegen...

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Detalles Bibliográficos
Autores principales: van Diggelen, Femke, Hrle, Dean, Apetri, Mihaela, Christiansen, Gunna, Rammes, Gerhard, Tepper, Armand, Otzen, Daniel Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430514/
https://www.ncbi.nlm.nih.gov/pubmed/30901378
http://dx.doi.org/10.1371/journal.pone.0213663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430514/
https://www.ncbi.nlm.nih.gov/pubmed/30901378
http://dx.doi.org/10.1371/journal.pone.0213663

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