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Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation
Parkinson’s Disease (PD) is a neurodegenerative disease for which there currently is no cure. Aggregation of the pre-synaptic protein α-synuclein (aSN) into oligomers (αSOs) is believed to play a key role in PD pathology, but little is known about αSO formation in vivo and how they induce neurodegen...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430514/ https://www.ncbi.nlm.nih.gov/pubmed/30901378 http://dx.doi.org/10.1371/journal.pone.0213663 |