Cargando…

Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens

Cytotoxic T lymphocytes (CTLs) with strong abilities to suppress HIV-1 replication and recognize circulating HIV-1 could be key for both HIV-1 cure and prophylaxis. We recently designed conserved mosaic T-cell vaccine immunogens (tHIVconsvX) composed of 6 Gag and Pol regions. Since the tHIVconsvX va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Chengcheng, Murakoshi, Hayato, Kuse, Nozomi, Akahoshi, Tomohiro, Chikata, Takayuki, Gatanaga, Hiroyuki, Oka, Shinichi, Hanke, Tomáš, Takiguchi, Masafumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430542/ https://www.ncbi.nlm.nih.gov/pubmed/30674626 http://dx.doi.org/10.1128/JVI.02142-18

Ejemplares similares

Role of Escape Mutant-Specific T Cells in Suppression of HIV-1 Replication and Coevolution with HIV-1
por: Zhang, Yu, et al.
Publicado: (2020)

Immunological Control of HIV-1 Disease Progression by Rare Protective HLA Allele
por: Zhang, Yu, et al.
Publicado: (2022)

Collaboration of a Detrimental HLA-B*35:01 Allele with HLA-A*24:02 in Coevolution of HIV-1 with T Cells Leading to Poorer Clinical Outcomes
por: Kuse, Nozomi, et al.
Publicado: (2021)

Epitope-dependent effect of long-term cART on maintenance and recovery of HIV-1-specific CD8(+) T cells
por: Kuse, Nozomi, et al.
Publicado: (2023)

Effect of Difference in Consensus Sequence between HIV-1 Subtype A/E and Subtype B Viruses on Elicitation of Gag-Specific CD8(+) T Cells and Accumulation of HLA-Associated Escape Mutations
por: Zhang, Yu, et al.
Publicado: (2021)

Control of HIV-1 Replication by CD8(+) T Cells Specific for Two Novel Pol Protective Epitopes in HIV-1 Subtype A/E Infection
por: Nguyen, Hung The, et al.
Publicado: (2022)

CD8(+) T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication
por: Murakoshi, Hayato, et al.
Publicado: (2018)

Impact of Micropolymorphism Outside the Peptide Binding Groove in the Clinically Relevant Allele HLA-C*14 on T Cell Responses in HIV-1 Infection
por: Chikata, Takayuki, et al.
Publicado: (2022)

Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control
por: Murakoshi, Hayato, et al.
Publicado: (2018)

Identification of Immunodominant HIV-1 Epitopes Presented by HLA-C*12:02, a Protective Allele, Using an Immunopeptidomics Approach
por: Chikata, Takayuki, et al.
Publicado: (2019)

Critical effect of Pol escape mutations associated with detrimental allele HLA-C(∗)15:05 on clinical outcome in HIV-1 subtype A/E infection
por: Murakoshi, Hayato, et al.
Publicado: (2021)

T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics
por: Akahoshi, Tomohiro, et al.
Publicado: (2020)

HIV-1 protective epitope-specific CD8(+) T cells in HIV-1-exposed seronegative individuals
por: Chikata, Takayuki, et al.
Publicado: (2023)

Long-term memory CD8(+) T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine
por: Kuse, Nozomi, et al.
Publicado: (2022)

Escape of Hepatitis C Virus from Epitope I Neutralization Increases Sensitivity of Other Neutralization Epitopes
por: Gu, Jun, et al.
Publicado: (2018)

A New Type of Satellite Associated with Cassava Mosaic Begomoviruses
por: Aimone, Catherine D., et al.
Publicado: (2021)

STING Ligand-Mediated Priming of Functional CD8(+) T Cells Specific for HIV-1-Protective Epitopes from Naive T Cells
por: Kuse, Nozomi, et al.
Publicado: (2021)

Two Novel DNAs That Enhance Symptoms and Overcome CMD2 Resistance to Cassava Mosaic Disease
por: Ndunguru, Joseph, et al.
Publicado: (2016)

Identification of Common CD8(+) T Cell Epitopes from Lassa Fever Survivors in Nigeria and Sierra Leone
por: Sakabe, Saori, et al.
Publicado: (2020)

Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants
por: Moyo-Gwete, Thandeka, et al.
Publicado: (2022)

HIV-1 Subtype C-Infected Children with Exceptional Neutralization Breadth Exhibit Polyclonal Responses Targeting Known Epitopes
por: Ditse, Zanele, et al.
Publicado: (2018)

Nuclear-Cytoplasmic Partitioning of Cucumber Mosaic Virus Protein 2b Determines the Balance between Its Roles as a Virulence Determinant and an RNA-Silencing Suppressor
por: Du, Zhiyou, et al.
Publicado: (2014)

Human Norovirus Epitope D Plasticity Allows Escape from Antibody Immunity without Loss of Capacity for Binding Cellular Ligands
por: Lindesmith, Lisa C., et al.
Publicado: (2019)

Discovery and Selection of Hepatitis B Virus-Derived T Cell Epitopes for Global Immunotherapy Based on Viral Indispensability, Conservation, and HLA-Binding Strength
por: de Beijer, Monique T. A., et al.
Publicado: (2020)

Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication In Vivo and Reduced Immunogenicity
por: Le Nouën, Cyril, et al.
Publicado: (2020)

Epitope-Containing Short Peptides Capture Distinct IgG Serodynamics That Enable Differentiating Infected from Vaccinated Animals for Live-Attenuated Vaccines
por: Xue, Qinghong, et al.
Publicado: (2020)

The impact of HLA-Cw*12:02 on control of HIV-1 infection
por: Koyanagi, M, et al.
Publicado: (2012)

Identification of novel HIV-1-derived HLA-E-binding peptides
por: Hannoun, Zara, et al.
Publicado: (2018)

Impact of Reinfection with SARS-CoV-2 Omicron Variants in Previously Infected Hamsters
por: Shiwa-Sudo, Nozomi, et al.
Publicado: (2023)

P16-06. Control of HIV-1 by HIV-1 Pol-specific CD8+ T cells in chronically HIV-1-infected Japanese cohort
por: Murakoshi, H, et al.
Publicado: (2009)

A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence
por: Ayllon, Juan, et al.
Publicado: (2014)

Impact of HLA Selection Pressure on HIV Fitness at a Population Level in Mexico and Barbados
por: Juarez-Molina, Claudia I., et al.
Publicado: (2014)

Virus and Host Factors Affecting the Clinical Outcome of Bluetongue Virus Infection
por: Caporale, Marco, et al.
Publicado: (2014)

Acute-Phase CD8 T Cell Responses That Select for Escape Variants Are Needed to Control Live Attenuated Simian Immunodeficiency Virus
por: Harris, Max, et al.
Publicado: (2013)

High Production Rates Sustain In Vivo Levels of PD-1(high) Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance
por: Petrovas, Constantinos, et al.
Publicado: (2013)

Regulatory T Cells Prevent Th2 Immune Responses and Pulmonary Eosinophilia during Respiratory Syncytial Virus Infection in Mice
por: Durant, Lydia R., et al.
Publicado: (2013)

Glycoprotein B Cleavage Is Important for Murid Herpesvirus 4 To Infect Myeloid Cells
por: Glauser, Daniel L., et al.
Publicado: (2013)

Herpes Simplex Virus 1 Targets the Murine Olfactory Neuroepithelium for Host Entry
por: Shivkumar, Maitreyi, et al.
Publicado: (2013)

Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
por: Maglennon, G. A., et al.
Publicado: (2014)

Delayed Sequelae of Neonatal Respiratory Syncytial Virus Infection Are Dependent on Cells of the Innate Immune System
por: Harker, James A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_j4dosd1a9cfjer9d04j496pbnk