Small Molecule Allosteric Inhibitors of BAX

BAX is a critical effector of the mitochondrial cell death pathway in response to a diverse range of stimuli in physiological and disease contexts. Upon binding by BH3-only proteins, cytosolic BAX undergoes conformational activation and translocation, resulting in mitochondrial outer membrane permea...

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Detalles Bibliográficos
Autores principales: Garner, Thomas P., Amgalan, Dulguun, Reyna, Denis E., Li, Sheng, Kitsis, Richard N., Gavathiotis, Evripidis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430685/
https://www.ncbi.nlm.nih.gov/pubmed/30718816
http://dx.doi.org/10.1038/s41589-018-0223-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430685/
https://www.ncbi.nlm.nih.gov/pubmed/30718816
http://dx.doi.org/10.1038/s41589-018-0223-0

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